Publications
Richards, B. A.; Goncalves, A. G.; Sullivan, M. O.; Chen, W. Engineering protein nanoparticles for drug delivery. Curr Opin Biotech 2024, 86. DOI: ARTN 10307010.1016/j.copbio.2024.103070.
Esther H. Roh, Millicent O. Sullivan, and Thomas H. Epps III ACS Applied Materials & Interfaces 2024 16 (11), 13399-13410 DOI: 10.1021/acsami.3c15424
Mullin, J. A.; Rahmani, E.; Kiick, K. L.; Sullivan, M. O. Growth factors and growth factor gene therapies for treating chronic wounds. Bioeng Transl Med 2023. DOI: 10.1002/btm2.10642.
Abeysinghe, A. A. D. T.; Young, E. J.; Rowland, A. T.; Dunshee, L. C.; Urandur, S.; Sullivan, M. O.; Kerfeld, C. A.; Keating, C. D. Interfacial Assembly of Bacterial Microcompartment Shell Proteins in Aqueous Multiphase Systems. Small 2023. DOI: 10.1002/smll.202308390.
Urandur, S.; Sullivan, M. O. Peptide-Based Vectors: A Biomolecular Engineering Strategy for Gene Delivery. Annu Rev Chem Biomol 2023, 14, 243-264. DOI: 10.1146/annurev-chembioeng-101121-070232.
Hwang, J.; Kiick, K. L.; Sullivan, M. O. VEGF-Encoding, Gene-Activated Collagen-Based Matrices Promote Blood Vessel Formation and Improved Wound Repair. Acs Appl Mater Inter 2023, 15 (13), 16434-16447. DOI: 10.1021/acsami.2c23022.
Hwang, J.; Huang, H. F.; Sullivan, M. O.; Kiick, K. L. Controlled Delivery of Vancomycin from Collagen-tethered Peptide Vehicles for the Treatment of Wound Infections. Mol Pharmaceut 2023. DOI: 10.1021/acs.molpharmaceut.2c00898.
Yur, D.; Sullivan, M. O.; Chen, W. Highly modular hepatitis B virus-like nanocarriers for therapeutic protein encapsulation and targeted delivery to triple negative breast cancer cells. J Mater Chem B 2023, 11 (18), 3985-3993. DOI: 10.1039/d3tb00445g.
Roh, E. H.; Sullivan, M. O.; Epps, T. H. A kinetic modeling platform for predicting the efficacy of siRNA formulations and. Star Protoc 2022, 3 (4). DOI: ARTN 10172310.1016/j.xpro.2022.101723.
Goncalves, A. G.; Hartzell, E. J.; Sullivan, M. O.; Chen, W. L. Recombinant protein polymer-antibody conjugates for applications in nanotechnology and biomedicine. Adv Drug Deliver Rev 2022, 191. DOI: ARTN 114570
10.1016/j.addr.2022.114570.
Hwang, J.; Kiick, K. L.; Sullivan, M. O. Modified hyaluronic acid-collagen matrices trigger efficient gene transfer and prohealing behavior in fibroblasts for improved wound repair. Acta Biomater 2022, 150, 138-153. DOI: 10.1016/j.actbio.2022.07.039.
Roh, H.E., Fromen, C.A., and Sullivan, M.O. "Inhalable mRNA vaccines for respiratory diseases: a roadmap" Current Opinion in Biotechnology (2021) DOI: 10.1016/j.copbio.2021.10.017
Dunshee, LC, Sullivan, MO, Kiick, KL. "Therapeutic nanocarriers comprising extracellular matrix-inspired peptides and polysaccharides" Expert opinion on drug delivery (2021). DOI: 10.1080/17425247.2021.1988925
Roh, H.E., Thomas, E.H., and Sullivan, M.O. "Kinetic Modeling to Accelerate the Development of Nucleic Acid Formulations" ACS Nano (2021) DOI: 10.1021/acsnano.1c04555
Yur, D., Lieser, R.M., Sullivan, M.O., and Chen, W. "Engineering bionanoparticles for improved biosensing and bioimaging" Current Opinion in Biotechnology (2021) DOI: 10.1016/j.copbio.2021.06.002
Hartzel, E.J., Lieser, R.M., Sullivan, M.O., and Chen, W. "Modular Hepatitis B Virus-like Particle Platform for Biosensing and Drug Delivery" ACS Nano (2020) DOI: 10.1021/acsnano.9b08756
Lieser, R.M., Yur, D., Sullivan, M.O., and Chen, W. "Site-specific bioconjugation approaches for enhanced delivery of protein therapeutics and protein drug carriers" Bioconjugate Chem (2020) DOI: 10.1021/acs.bioconjchem.0c00456
Thapa, R.K., Margolis, D.J., Kiick, K.L., and Sullivan, M.O. "Enhanced wound healing via collagen-turnover-driven transfer of PDGF-BB gene in a murine wound model" ACS Applied Bio Materials. (2020) DOI: 10.1016/j.actbio.2019.12.014
Hwang, J, Sullivan, MO, Kiick, KL. "Targeted drug delivery via the use of ECM-mimetic materials." Front. Bioeng. Biotechnol. (2020). DOI: 10.3389/fbioe.2020.00069
Thapa, R.K., Kiick, K.L., and Sullivan, M.O. "Encapsulation of collagen mimetic peptide-tethered vancomycin liposomes in collagen-based scaffolds for infection control in wounds" Acta Biomaterialia. (2019) DOI: 10.1016/j.actbio.2019.12.014
Dunshee, LC, Sullivan, MO, Kiick, KL. Manipulation of the dually thermoresponsive behavior of peptide‐based vesicles through modification of collagen‐like peptide domains. Bioeng Transl Med. (2019). DOI: 10.1002/btm2.10145
Palmese, L.L., Thapa, R.K., Sullivan, M.O. and Kiick, K.L. "Hybrid hydrogels for biomedical applications." Current Opinion in Chemical Engineering. (2019). DOI: 10.1016/j.coche.2019.02.010
Lieser, R.M., Chen, W., and Sullivan, M.O. "Controlled EGFR ligand display on cancer suicide enzymes via UAA engineering for enhanced intracellular delivery in breast cancer cells" Bioconjugate Chemistry (2018). DOI: 10.1021/acs.bioconjchem.8b00783
Munsell, E.K., Fang, B., Sullivan, M.O. "Histone-Mimetic Gold Nanoparticles as Versatile Scaffolds for Gene Transfer and Chromatin Analysis," Bioconjugate Chemistry (2018). DOI: 10.1021/acs.bioconjchem.8b00611
Thapa, R.K., Sullivan, M.O. "Gene delivery by peptide-assisted transport," Current Opinion in Biomedical Engineering (2018). DOI: 10.1016/j.cobme.2018.10.002
Thomas, E.H., Vi, T. and Sullivan, M.O. "Design and development of a robust photo-responsive block copolymer framework for tunable nucleic acid delivery and efficient gene silencing." Polymer Journal (2018) DOI: 10.1038/s41428-018-0077-z
Munsell, E.V., Kurpad, D.S., Freeman, T.A., and Sullivan, M.O. "Histone-targeted gene transferof bone morphogenetic protein-2 enhances mesenchymal stem cell chondrogenic differentiation," Acta Biomaterialia. (2018) DOI: 10.1016/j.actbio.2018.02.021
Urello, M.A., Kiick, K.L., and Sullivan, M.O. "ECM turnover-stimulated gene delivery through collagen-mimetic peptide-plasmid integration in collagen," Acta Biomaterialia. (2017) DOI: 10.1016/j.actbio.2017.08.038
Greco, C.T., Akins, R.E., Epps III, T.H., and Sullivan, M.O. "Attenuation of Maladaptive Responses in Aortic Adventitial Fibroblasts through Stimuli-Triggered siRNA Release from Lipid-Polymer Nanocomplexes," Advanced Biosystems. (2017) DOI: 10.1002/adbi.201700099
Greco C.T., Epps III, T.H., and Sullivan, M.O. “Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nancarriers,” Journal of Visualized Experiments: JoVE. (2017) DOI: 10.3791/55803
Greco, C.T., Andrechak, J.C., Epps III, T.H., and Sullivan, M.O. "Anionic Polymer and Quantum Dot Excipients to Facilitate siRNA Release and Self-Reporting of Disassembly in Stimuli-Responsive Nanocarrier Formulations," Biomacromolecules. (2017) DOI: 10.1021/acs.biomac.7b00265
Greco, C.T., Muir, V.M., Epps III, T.H., and Sullivan, M.O. "Efficient Tuning of siRNA Dose Response by Combining Mixed Polymer Nanocarriers with Simple Kinetic Modeling," Acta Biomaterialia. (2017). DOI: 10.1016/j.actbio.2017.01.003
Urello, M.A., Kiick, K.L., and Sullivan, M.O. "Integration of Growth Factor Gene Delivery with Collagen-Triggered Wound Repair Cascades using Collagen-Mimetic Peptides," Bioengineering & Translational Medicine. (2016). DOI: 10.1016/j.actbio.2017.01.003
Greco, C.T., Epps III, T.H., and Sullivan, M.O. "Precise Spatiotemporal Control of Gene Expression Through the Mechanistic Design of Polymer Nanocarriers," ACS Biomaterials Science and Engineering. (2016). DOI: 10.1021/acsbiomaterials.6b00336
Ross, N.L. and Sullivan, M.O. “Overexpression of caveolin-1 in inflammatory breast cancer cells enables IBC-specific gene delivery and prodrug conversion using histone-targeted polyplexes,” Biotechnology and Bioengineering. (2016). DOI: 10.1002/bit.26022
Munsell EV, Ross NL, Sullivan MO. "Journey to the center of the cell: current nanocarrier design strategies targeting biopharmaceuticals to the cytoplasm and nucleus," Curr. Pharm. Des. 22(9): (2016) 1227-44. DOI:
Walsh, J.W., Hoffstad, O.J., Sullivan, M.O. , and Margolis, D.J. “Association of Diabetic Foot Ulcer and Death in a Population-Based Cohort from the United Kingdom,” Diabetic Medicine, (2016). DOI: 10.1111/dme.13054
Ross, N.L. and Sullivan, M.O. “Importin-4 Regulates Gene Delivery by Enhancing Nuclear Retention and Chromatin Deposition by Polyplexes,” Molecular Pharmaceutics, 12(12): (2015) 4488-4497. DOI: 10.1021/acs.molpharmaceut.5b00645
Foster, A.A., Ross, N.L., and Sullivan, M.O. “Fluorescent Dye Incorporation Causes Weakened Gene Association and Intracellular Aggregate Formation in Non-viral Carriers,” Journal of Gene Medicine, 17: (2015)69-79. DOI: 10.1002/jgm
Ross, N.L., Munsell, E.V., Sabanayagam, C., and Sullivan, M.O. “Histone-Targeted Polyplexes Avoid Endosomal Escape and Enter the Nucleus During Post-mitotic Redistribution of ER Membranes,” Molecular Therapy Nucleic Acids, 4, e226, (2015). DOI: 10.1038/mtna.2015.2
Foster, A.A., Green, M.D., Greco, C.T., Roy, R., Epps III, T.H., and Sullivan, M.O. “Light-Mediated Activation of siRNA Release in Diblock Copolymer Assemblies for Controlled Gene Silencing,” Advanced Healthcare Materials, 4(5): (2014) 760-770. DOI: 10.1002/adhm.201400671
Murphy, R.P., Kelley, E.G., Rogers, S., Sullivan, M.O. , and Epps, III, T.H. “Unlocking Chain Exchange in Block Polymer Micelles at the Air-water Interface: Influence of Agitation,” ACS Macro Letters, 3: (2014) 1106-1111. DOI: 10.1021/mz500435d
Urello, M.A., Kiick, K.L., and Sullivan, M.O. “A CMP-based Method for Tunable, Cell-mediated Gene Delivery from Collagen Scaffolds,” Journal of Materials Chemistry B, 2(46): (2014) 8174-8185. DOI: 10.1039/C4TB01435A
Green, M.D., Foster, A.A., Greco, C.T., Roy, R., Lehr, R.M., Epps, III, T.H., and Sullivan, M.O. “Catch and Release: Photocleavable Cationic Diblock Copolymers as a Potential Platform for Nucleic Acid Delivery,” Polymer Chemistry, 5: (2014) 5535-5541. DOI: 10.1039/C4PY00638K
Kelley, E.G., Murphy, R.P., Seppala, J.E., Smart, T.P., Hann, S.D., Sullivan, M.O., and Epps, III, T.H. “Size evolution of highly amphiphilic macromolecular solution assemblies via a distinct bimodal pathway” Nature Communications, 5: (2014) 3599. DOI: 10.1038/ncomms4599
Kelley, E.G., Albert, J.N.L., Sullivan, M.O., and Epps, III, T.H. “Stimuli-Responsive Copolymer Solution and Surface Assemblies for Biomedical Applications” Chem. Soc. Rev. 42(17): (2013) 7057-7071. DOI: 10.1039/C3CS35512H
Patterson, J.P., Kelley, E.G., Murphy R.P, Moughton, A.O., Robin, M.P., Lu, A., Colombani, O., Chassenieux, C., Cheung, D., Sullivan, M.O., Epps, III, T.H., and O’Reilly, R.K. “Structural Characterization of Amphiphilic Homopolymer Micelles Using Light Scattering, SANS, and Cryo-TEM” Macromolecules 46(15): (2013) 6319-6325. DOI: 10.1021/ma4007544
Larsen, J.D., Ross, N.L., and Sullivan, M.O. “Requirements for the Nuclear Entry of Polyplexes and Nanoparticles During Mitosis” J. Gene Med. 14(9-10): (2012) 580-589.
Reilly, M.J., Larsen, J.D., and Sullivan, M.O. “Polyplexes Traffic Through Caveolae to the Golgi and Endoplasmic Reticulum en Route to the Nucleus.” Mol. Pharmaceutics. 9(5): (2012) 1280-1290.
Larsen, J.D., Reilly, M.J., and Sullivan, M.O., “Using the Epigenetic Code to Promote the Unpackaging and Transcriptional Activation of DNA Polyplexes for Gene Delivery.” Mol. Pharmaceutics. 9(5): (2012) 1041-1051.
Reilly, M.J., Larsen, J.D., and Sullivan, M.O. “Histone H3 Tail Peptides and Poly(ethylenimine) Have Synergistic Effects for Gene Delivery.” Mol. Pharmaceutics. 9(5): (2012) 1031-1040.
Kelley, E.G.*, Smart, T.P.*, Jackson, A.J., Sullivan, M.O., and Epps, III, T.H. “Structural Changes in Block Copolymer Micelles Induced by Cosolvent Mixtures.” Soft Matter. 7(15): (2011) 7094-7102.
Blocker, K.M. and Sullivan, M.O. “Non-viral Gene Delivery for Applications in Regenerative Medicine.” For Engineering Biomaterials for Regenerative Medicine: Novel Technologies for Clinical Applications. Sujata N. Bhatia (ed.), Springer, 2011.
Blocker, K.M., Kiick, K.L., and Sullivan, M.O. “Surface Immobilization of Plasmid DNA with a Cell-Responsive Tether for Substrate-Mediated Gene Delivery.”Langmuir. 27(6): (2011) 2739-2746.
Sullivan, M.O. “Self-Unpackaging Gene Delivery Scaffolds.” Organelle-Specific Pharmaceutical Nanotechnology. Ed. Volkmar Weissig and Gerard G. M. D’Souza. (New Jersey: John Wiley & Sons, Inc., 2010). 207-230.
Millili, P.G., Yin, D.H., Fan, H., Naik, U.P., and Sullivan, M.O. “Formulation of a Peptide Nucleic Acid Based Nucleic Acid Delivery Construct.” Bioconjugate Chem. 21: (2010) 445-455.
Millili, P.G., Selekman, J.A., Blocker, K.M., Johnson, D.A., Naik, U.P., and Sullivan, M.O. “Structural and Functional Consequences of Poly(ethylene glycol) Inclusion on DNA Condensation for Gene Delivery.” Microscopy Research and Technique. 73: (2010) 866–877.
Millili, P.G., Naik, U.P., and Sullivan, M.O., “Multiscale Experimental Biology and Nucleic Acid Delivery: Cancer Therapeutic Approaches via Rational Formulation Design.” Cancer Therapy, 7: (2009) 429-448. Invited.
Naik, M., Nigam, A., Padmini, M., Millili, P., Czymmek, K., Sullivan, M., and Naik, U. , “CIB1 Deficiency Results in Impaired Thrombosis: The Potential Role of CIB1 in Outside-in Signaling Through Integrin αIIbβ3.” J. Thromb. Haem. 7: (2009) 1906-1914.
2008
Sullivan, M.M., Barker, T.H., Funk, S.E., Puolakkainen, P.A., and Sage, E.H. , “Altered Tissue Repair in Hevin-null Mice: Inhibition of Fibroblast Migration by a Matricellular SPARC Homolog.” Wound Rep. Regen. 16: (2008) 310-319.
2006
Sullivan, M.M., Barker, T.H., Funk, S.E., Karchin, A., Seo, N.S., Hook, M., Sanders, J.E., Starcher, B., Wight, T.N., Puolakkainen, P.A., and Sage, E.H. , “Matricellular Hevin Regulates Decorin Production and Collagen Assembly.” J. Biol. Chem. 281: (2006) 27621-27632.
2004
Brekken, R.A., Sullivan, M.M., Workman, G., Bradshaw, A.D., Carbon, J., Siadak, A., Murri, C., Framson, P.E., and Sage, E.H. “Expression and Characterization of Murine Hevin (SC-1), a Member of the SPARC Family of Matricellular Proteins.” J. Histochem. Cytochem. 52: (2004) 735-748.
Sullivan, M.M. and Sage, E.H. “Hevin, a Matricellular Glycoprotein and Potential Tumor-Suppressor of the SPARC/BM-40/Osteonectin Family.” Int. J. Biochem. Cell Biol. 36: (2004) 991-996.
2003
Sullivan, M.M.O., Green, J.J., and Przybycien, T.M. “Development of a Novel Gene Delivery Scaffold Utilizing Colloidal Gold-Polyethylenimine Conjugates for DNA Condensation.” Gene Ther. 10: (2003) 1882-1890.
1994
Vandervelde, T.J., Ow, M.M., Thorpe, W.R., Hartmann, W.M., and Rakerd, B. “Localizing Broadband Noise in a Reverberation Room.” J. Acoust. Soc. Amer. 96: (1994) 3257.